N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide
CAS No.:1430724-30-3
Molecular Formula:C₂₁H₁₉N₇O₂S
Molecular Weight:433.494
Hs Code.:

Synonyms:N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

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Chemical Property of N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

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Technology Process of N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

There total 14 articles about N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1430728-00-9
3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)aniline

: 124-63-0
methanesulfonyl chloride

: 1430724-30-3
N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 364-75-0
1-fluoro-4-iodo-2-nitro-benzene

: 1430724-30-3
N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

2: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C

3: 0.5 h / 100 °C

4: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

6: sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; dimethyl sulfoxide / 12 h / 20 °C

7: sodium hydroxide / ethanol / 3 h / 100 °C

8: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; ammonium chloride; sodium L-ascorbate; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1430724-30-3
N-(3-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-iodo-succinimide; trifluorormethanesulfonic acid / 1 h / 0 - 20 °C

2: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

3: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C

4: 0.5 h / 100 °C

5: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

7: sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; dimethyl sulfoxide / 12 h / 20 °C

8: sodium hydroxide / ethanol / 3 h / 100 °C

9: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; potassium fluoride; N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; copper(ll) sulfate pentahydrate; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; ammonium chloride; sodium L-ascorbate; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;