tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate
CAS No.:1185758-64-8
Molecular Formula:C₁₉H₂₈BrNO₄
Molecular Weight:414.34
Hs Code.:

Synonyms:tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 163934-00-7
4-bromo-2-(methoxymethyl)phenol

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1185758-64-8
tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 3h;

Reference yield: 55.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 1185758-64-8
tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

: 1185758-65-9
tert-butyl 4-[4-(dimethoxyboranyl)-2-(methoxymethyl) phenoxymethyl]piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

Reference yield: 33.0%

: 1185758-64-8
tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate

: 343262-51-1
2-bromo-5-methanesulfonylpyridine

: 1185758-51-3
tert-butyl 4-({2-(methoxymethyl)-4-[5-(methylsulfonyl)pyridin-2-yl]phenoxy}methyl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-{[4-bromo-2-(methoxymethyl)phenoxy]methyl}piperidine-1-carboxylate; With potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 90 ℃; for 3h;

2-bromo-5-methanesulfonylpyridine; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 2.5h;