(S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

Base Information

Chemical Name:(S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester
CAS No.:190904-34-8
Molecular Formula:C₂₁H₃₂N₂O₇
Molecular Weight:424.494
Hs Code.:

Synonyms:(S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

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Chemical Property of (S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

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Technology Process of (S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

There total 2 articles about (S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 67-56-1
methanol

: 129081-49-8,129081-50-1
((S)-5-tert-Butoxycarbonylamino-7,7,7-tris-ethylsulfanyl-6-hydroxy-heptyl)-carbamic acid benzyl ester

: 190904-34-8
(S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

Guidance literature:: With mercury dichloride; mercury(II) oxide; In water;
DOI:10.1016/S0040-4039(00)88812-7

Reference yield:

: 82689-16-5
benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate

: 190904-34-8
(S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) THF, hexane, 20 min, -78 deg C 2) 2.5h, -78 deg C

2: 70 percent / HgCl₂, HgO / H₂O

With n-butyllithium; mercury dichloride; mercury(II) oxide; In water;
DOI:10.1016/S0040-4039(00)88812-7

Reference yield:

: 190904-34-8
(S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-2-hydroxy-heptanoic acid methyl ester

: 129081-54-5,129081-60-3
Ac-Ala-D,L-Lys-CO₂CH₃*HOTs*H₂O

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / ethyl acetate

2: 1) isobutyl chloroformate

3: HCl / ethyl acetate

4: Et₃N

5: oxalyl chloride, DMSO, Et₃N

6: H₂ / Pd/C / methanol

With hydrogenchloride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0040-4039(00)88812-7