BUTYL 4-BROMOBUTYRATE

Base Information

• Chemical Name: BUTYL 4-BROMOBUTYRATE
• CAS No.: 3540-75-8
• Molecular Formula: C8H15 Br O2
• Molecular Weight: 223.11
• Hs Code.: 2915900090
• Mol file: 3540-75-8.mol

Synonyms:Butyricacid, 4-bromo-, butyl ester (7CI,8CI)

Chemical Property of BUTYL 4-BROMOBUTYRATE

Chemical Property:

• Vapor Pressure: 0.0432mmHg at 25°C
• Refractive Index: 1.46
• Boiling Point: 238.1°C at 760 mmHg
• Flash Point: 120.8°C
• PSA: 26.30000
• Density: 1.258g/cm³
• LogP: 2.50480
• Solubility.: CDCl3

Purity/Quality:

99% ^*data from raw suppliers

BUTYL 4-BROMOBUTYRATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Butyl 4-Bromobutanoate is an intermediate for the synthesis of Bepotastine N-Butyl Ester (B317020), which is an impurity of Bepotastine, a 2nd generation antihistamine that is used to treat allergic rhinitis and urticaria/pruritus (also known as hives).

Technology Process of BUTYL 4-BROMOBUTYRATE

There total 4 articles about BUTYL 4-BROMOBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bromobutyric acid (2623-87-2) + butan-1-ol (71-36-3) → butyl 4-bromobutanoate (3540-75-8)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1142/S1088424610002744

Reference yield: 60.0%

4-bromo-1-(2,3,4,5,6-pentamethylphenyl)butan-1-one + butan-1-ol (71-36-3) → butyl 4-bromobutanoate (3540-75-8)

Guidance literature:

4-bromo-1-(2,3,4,5,6-pentamethylphenyl)butan-1-one; With bromine; In dichloromethane; at -17 ℃; for 0.25h; Sealed tube;

butan-1-ol; In water; at -17 - 25 ℃; for 16h; Sealed tube;

DOI:10.1055/s-0040-1707289

Reference yield:

4-butanolide (96-48-0) + butan-1-ol (71-36-3) → butyl 4-bromobutanoate (3540-75-8)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/jm00329a050

upstream raw materials:

4-butanolide

butan-1-ol

bromobutyric acid

Downstream raw materials:

<4-(3-Jod-4-methoxy-benzoyloxy)-buttersaeure>-butylester

<4-(2-Jod-benzoyloxy)-buttersaeure>-butylester

<4-(4-Jod-benzoyloxy)-buttersaeure>-butylester

<4-(3-Jod-benzoyloxy)-buttersaeure>-butylester

Refernces

• 1、 Mudyiwa, Mercy,Ndinguri, Margaret W.,Soper, Steven A.,Hammer, Robert P.. "Microwave assisted solid-phase synthesis of substituted tetraazaporphyrins and a phthalocyanine-peptide conjugate". body text. p. 891 - 903. Retrieved 2011/12/02.