oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

Base Information

Chemical Name:oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester
CAS No.:866457-11-6
Molecular Formula:C₃₂H₃₀O₄
Molecular Weight:478.588
Hs Code.:

Synonyms:oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

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Technology Process of oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

There total 5 articles about oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 866457-06-9
(1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethanol

: 611-73-4
Benzoylformic acid

: 866457-11-6
oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866457-02-5
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

: 866457-11-6
oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.125 g / p-TsOH / methanol; CH₂Cl₂ / 20 °C

2: 75 percent / diisopropylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; toluene-4-sulfonic acid; diisopropyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

: 866457-11-6
oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / I₂; PPh₃; imidazole / toluene / Heating

2: 90 percent / LiBEt₃H / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 67 °C

3: 0.125 g / p-TsOH / methanol; CH₂Cl₂ / 20 °C

4: 75 percent / diisopropylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With 1H-imidazole; dmap; iodine; lithium triethylborohydride; toluene-4-sulfonic acid; triphenylphosphine; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2005.06.033