[2S-(2α(1R,2S),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

Base Information

Chemical Name:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol
CAS No.:866456-95-3
Molecular Formula:C₃₆H₄₄O₄
Molecular Weight:540.743
Hs Code.:

Synonyms:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

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Chemical Property of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

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Technology Process of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

There total 1 articles about [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 866456-93-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield: 93.0%

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

: 866457-00-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In toluene; Heating;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

: 866457-06-9
(1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / I₂; PPh₃; imidazole / toluene / Heating

2: 90 percent / LiBEt₃H / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 67 °C

3: 0.125 g / p-TsOH / methanol; CH₂Cl₂ / 20 °C

With 1H-imidazole; iodine; lithium triethylborohydride; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2005.06.033