[2S-(2α(1S,2R),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Base Information

Chemical Name:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran
CAS No.:866457-02-5
Molecular Formula:C₃₆H₄₄O₃
Molecular Weight:524.744
Hs Code.:

Synonyms:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

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Chemical Property of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

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Technology Process of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

There total 3 articles about [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 866457-00-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

: 866457-02-5
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 67 ℃; for 16h;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

: 866457-02-5
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / I₂; PPh₃; imidazole / toluene / Heating

2: 90 percent / LiBEt₃H / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 67 °C

With 1H-imidazole; iodine; lithium triethylborohydride; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-93-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

: 866457-02-5
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 93 percent / I₂; PPh₃; imidazole / toluene / Heating

3: 90 percent / LiBEt₃H / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 67 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; lithium triethylborohydride; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; toluene;
DOI:10.1016/j.tetasy.2005.06.033