endoxifen ethyl formate

Base Information

• Chemical Name: endoxifen ethyl formate
• CAS No.: 1372937-21-7
• Molecular Formula: C₂₈H₃₁NO₄
• Molecular Weight: 445.558
• Mol file: 1372937-21-7.mol

Synonyms:endoxifen ethyl formate

Chemical Property of endoxifen ethyl formate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of endoxifen ethyl formate

There total 7 articles about endoxifen ethyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2-(4-(1-(4-benzyloxyphenyl)-2-phenylbut-1-enyl)phenyloxy)ethyl)methylcarbamic acid ethyl ester (1372937-20-6) → endoxifen ethyl formate (1372937-21-7)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethyl acetate; for 0.166667h; under 760.051 Torr;

Reference yield:

chloroformic acid ethyl ester (541-41-3) + (E/Z)-4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol (110025-28-0) → endoxifen ethyl formate (1372937-21-7)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 0 - 5 ℃; for 8h;

Reference yield:

4,4'-Dihydroxybenzophenone (611-99-4) → endoxifen ethyl formate (1372937-21-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 48 h / 60 °C

2: zinc; titanium tetrachloride / tetrahydrofuran / 18 h / -10 - 80 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 - 70 °C

4: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 0.17 h / 760.05 Torr

With hydrogen; titanium tetrachloride; potassium carbonate; caesium carbonate; zinc; 5%-palladium/activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetone; 2: McMurry Reaction;

upstream raw materials:

4,4'-Dihydroxybenzophenone

2-[N-(ethyloxycarbonyl)-N-methylamino]ethanol

4-hydroxy-4'-benzyloxybenzophenone

ethyl 2-iodoethyl(methyl)carbamate