6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin

Base Information

• Chemical Name: 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin
• CAS No.: 365568-75-8
• Molecular Formula: C₅₄H₇₇NO₁₅
• Molecular Weight: 980.203
• Mol file: 365568-75-8.mol

Synonyms:6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin

Chemical Property of 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin

There total 3 articles about 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C63H94N2O16 (365568-74-7) → 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin (365568-75-8)

Guidance literature:

With hydrogenchloride; sodium nitrite;

DOI:10.1016/j.bmcl.2012.06.092

Reference yield:

6-O-propargyl erythromycin A (198482-62-1) → 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin (365568-75-8)

Guidance literature:

Reference yield:

benzoic acid anhydride (93-97-0) → 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin (365568-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / ethyl acetate

2: potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide

3: hydrogenchloride; sodium nitrite

With hydrogenchloride; dmap; potassium tert-butylate; triethylamine; sodium nitrite; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.bmcl.2012.06.092

upstream raw materials:

6-O-propargyl erythromycin A

C₆₃H₉₄N₂O₁₆

benzoic acid anhydride

Downstream raw materials:

C₅₅H₇₆N₂O₁₅

C₅₇H₇₉N₃O₁₄

benzoic acid 4-dimethylamino-2-{11-ethyl-2,4,6,8,12,19-hexamethyl-7,9,14-trioxo-4-[4-(4-pyridin-2-yl-phenyl)-but-2-ynyloxy]-10,13-dioxa-15,18-diaza-tricyclo[10.6.2.0^15,20]eicos-1⁽¹⁸⁾-en-5-yloxy}-6-methyl-tetrahydro-pyran-3-yl ester

benzoic acid 4-dimethylamino-2-{11-ethyl-2,4,6,8,12,19-hexamethyl-7,9,14-trioxo-4-[4-(4-thiophen-2-yl-phenyl)-but-2-ynyloxy]-10,13-dioxa-15,18-diaza-tricyclo[10.6.2.0^15,20]eicos-1⁽¹⁸⁾-en-5-yloxy}-6-methyl-tetrahydro-pyran-3-yl ester