((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine

Base Information

• Chemical Name: ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine
• CAS No.: 353525-64-1
• Molecular Formula: C₁₆H₂₉NOSi
• Molecular Weight: 279.498
• Mol file: 353525-64-1.mol

Synonyms:((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine

Chemical Property of ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine

There total 2 articles about ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(1S,2R)-(+)-ephedrine (321-98-2,7009-81-6,90-83-5,6912-63-6) + tert-butyldimethylsilyl chloride (18162-48-6) → ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine (353525-64-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; benzene; at 20 ℃; for 15h;

DOI:10.1021/jm0004547

Reference yield: 60.0%

(+)-(1S,2R)-ephedrine hydrochloride (24221-86-1) + tert-butyldimethylsilyl chloride (18162-48-6) → ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine (353525-64-1)

Guidance literature:

(+)-(1S,2R)-ephedrine hydrochloride; tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Inert atmosphere;

Inert atmosphere;

DOI:10.1021/acs.orglett.5b00801

Reference yield:

N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate (25468-31-9) + ((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine (353525-64-1) → C19H36N2OSi

Guidance literature:

((1R,2S)-2-((1,1-dimethylethyl)dimethylsilyloxy)-1-methyl-2-phenylethyl)methylamine; With methylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.75h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00801

upstream raw materials:

(1S,2R)-(+)-ephedrine

tert-butyldimethylsilyl chloride

(+)-(1S,2R)-ephedrine hydrochloride