O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine

Base Information

• Chemical Name: O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine
• CAS No.: 62930-00-1
• Molecular Formula: C₃₄H₃₅N₂O₉P
• Molecular Weight: 646.634

Synonyms:O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine

Chemical Property of O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine

Chemical Property:

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Technology Process of O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine

There total 3 articles about O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Bis<1,2-dimethylethenylene>pyrophosphate (55894-94-5) + 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine (42926-80-7) → O3'-(4,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphol-2-yl)-O5'-(4-methoxy-trityl)-thymidine (62930-00-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1055/s-1983-30368

Reference yield:

→ O3'-(4,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphol-2-yl)-O5'-(4-methoxy-trityl)-thymidine (62930-00-1)

Guidance literature:

5'-O-p-Methoxytritylthymidin (3), Pyrophosphat 1, Nicotinamid;

DOI:10.1021/jo00439a008

Reference yield:

→ O3'-(4,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphol-2-yl)-O5'-(4-methoxy-trityl)-thymidine (62930-00-1)

Guidance literature:

/BRN= 772510/, /BRN= 549023/, /BRN= 383619/;

upstream raw materials:

Bis<1,2-dimethylethenylene>pyrophosphate

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

Downstream raw materials:

C₆₄H₇₀N₉O₁₆P

Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

Thymidylyl(3'->5')puromycin triethylammonium salt

Thymidylyl(3'->5')puromycin

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