[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

Base Information

Chemical Name:[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester
CAS No.:1418293-43-2
Molecular Formula:C₁₂H₉F₃N₂O₃
Molecular Weight:286.21
Hs Code.:

Synonyms:[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

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Chemical Property of [4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

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Technology Process of [4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

There total 8 articles about [4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 67-56-1
methanol

: 2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetonitrile

: 1418293-43-2
[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

Guidance literature:: With chloro-trimethyl-silane; at 65 ℃; for 12h;

Reference yield:

: 1011264-24-6
[4-(N-hydroxycarbamimidoyl)-phenyl]-acetic acid methyl ester

: 407-25-0
trifluoroacetic anhydride

: 1418293-43-2
[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 22h;

Reference yield:

: 3-(4-methylphenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole

: 1418293-43-2
[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 18 h / 65 - 70 °C / Inert atmosphere

2: tetrabutylammonium hydrofluoride / tetrahydrofuran; acetonitrile / 3 h / 0 - 20 °C

3: chloro-trimethyl-silane / 12 h / 65 °C

With N-Bromosuccinimide; chloro-trimethyl-silane; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; acetonitrile;