3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid

Base Information

• Chemical Name: 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid
• CAS No.: 1356570-98-3
• Molecular Formula: C₂₃H₃₀O₃Si
• Molecular Weight: 382.575
• Mol file: 1356570-98-3.mol

Synonyms:3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid

Chemical Property of 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid

There total 3 articles about 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H11O3(1-)*Na(1+) (1356570-97-2) + tert-butylchlorodiphenylsilane (58479-61-1) → 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid (1356570-98-3)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201101343

Reference yield:

5,6-dihydro-pyran-2-one (3393-45-1) → 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid (1356570-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 5 h / 80 °C / Inert atmosphere

3.1: 1H-imidazole / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201101343

Reference yield:

4-vinyltetrahydro-2H-pyran-2-one (89030-33-1) → 3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)pent-4-enoic acid (1356570-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 5 h / 80 °C / Inert atmosphere

2: 1H-imidazole / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201101343

upstream raw materials:

C₇H₁₁O₃^(1-)*Na⁽¹⁺⁾

tert-butylchlorodiphenylsilane

5,6-dihydro-pyran-2-one

4-vinyltetrahydro-2H-pyran-2-one

Downstream raw materials:

3-(2-((4-methoxybenzyl)oxy)ethyl)-N,N-dimethylpent-4-enamide

3-(2-((4-methoxybenzyl)oxy)ethyl)-1-(pyrrolidin-1-yl)pent-4-en-1-one

3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-1-(pyrrolidin-1-yl)pent-4-en-1-one

C₂₄H₃₂O₃Si