2-Methoxy-6-methyl-4-pyridinecarboxylicacidethylester

Base Information

• Chemical Name: 2-Methoxy-6-methyl-4-pyridinecarboxylicacidethylester
• CAS No.: 262296-07-1
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 262296-07-1.mol

Synonyms:2-Methoxy-6-methylisonicotinicacid ethyl ester

Chemical Property of 2-Methoxy-6-methyl-4-pyridinecarboxylicacidethylester

Chemical Property:

• Refractive Index: 1.501
• PSA: 48.42000
• LogP: 1.57530

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl2-methoxy-6-methylisonicotinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-6-methyl-4-pyridinecarboxylicacidethylester

There total 3 articles about 2-Methoxy-6-methyl-4-pyridinecarboxylicacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 6-chloro-2-methoxy-pyridine-4-carboxylate (106719-08-8) + dimethyl zinc(II) (544-97-8) → 2-methoxy-6-methyl-4-pyridinecarboxylic acid ethyl ester (262296-07-1)

Guidance literature:

Pd(dppf); In 1,4-dioxane; toluene; at 75 ℃; for 18h;

Reference yield:

2-hydroxy-6-methylisonicotinic acid ethyl ester (150190-03-7) + methyl iodide (74-88-4) → 2-methoxy-6-methyl-4-pyridinecarboxylic acid ethyl ester (262296-07-1)

Guidance literature:

With silver carbonate; In toluene; at 100 ℃; for 4h;

Reference yield:

2-chloro-6-methoxy-isonicotinic acid (15855-06-8) → 2-methoxy-6-methyl-4-pyridinecarboxylic acid ethyl ester (262296-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 18 h / 70 °C

2: Pd(dppf) / toluene; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere

With sulfuric acid; Pd(dppf); In 1,4-dioxane; toluene;

upstream raw materials:

Ethyl 6-chloro-2-methoxy-pyridine-4-carboxylate

dimethyl zinc(II)

2-hydroxy-6-methylisonicotinic acid ethyl ester

methyl iodide

Refernces

• 1、 -. "PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS". Page/Page column 32. . Retrieved 2011/09/20.
• 2、 -. "NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES". Page/Page column 59. . Retrieved 2009/10/22.