8-benzylquinoline

Base Information

• Chemical Name: 8-benzylquinoline
• CAS No.: 28748-19-8
• Molecular Formula: C₁₆H₁₃N
• Molecular Weight: 219.286
• Mol file: 28748-19-8.mol

Synonyms:8-benzylquinoline

Chemical Property of 8-benzylquinoline

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 8-benzylquinoline

There total 11 articles about 8-benzylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

8-methylquinoline (611-32-5) + dibenzoyl peroxide (94-36-0) → 8-benzylquinoline (28748-19-8)

Guidance literature:

With palladium diacetate; In acetic acid; acetonitrile; for 2h; Heating; Inert atmosphere;

DOI:10.1021/ol900756g

Reference yield: 72.0%

8-methylquinoline (611-32-5) + diphenyliodonium tetrafluoroborate → 8-benzylquinoline (28748-19-8)

Guidance literature:

With palladium diacetate; acetic anhydride; at 100 ℃; for 12h;

DOI:10.1021/ja051402f

Reference yield: 59.0%

8-methylquinoline (611-32-5) + palladium diacetate (3375-31-3) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 8-(fluoromethyl)quinoline (897366-48-2) + 8-benzylquinoline (28748-19-8) + (quinolin-8-yl)methyl acetate (79663-29-9)

Guidance literature:

With 1-fluoro-2,4,6-trimethylpyridin-1-ium tetrafluoroborate; at 110 ℃; for 1h; microwave irradiation;

DOI:10.1021/ja061943k

upstream raw materials:

8-methylquinoline

palladium diacetate

benzene

8-(fluoromethyl)quinoline

Downstream raw materials:

8-benzyl-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 Parmar, Diksha,Kumar, Rohit,Kumar, Rakesh,Sharma, Upendra. "Ru(II)-Catalyzed Chemoselective C(sp3)-H Monoarylation of 8-Methyl Quinolines with Arylboronic Acids". . p. 11844 - 11855. Retrieved 2020/10/23.
• 2、 Wang, Xiaoming,Yu, Da-Gang,Glorius, Frank. "CpRhIII-Catalyzed Arylation of C(sp3) Bonds". supporting information. p. 10280 - 10283. Retrieved 2015/09/01.