1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole

Base Information

• Chemical Name: 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole
• CAS No.: 1427475-97-5
• Molecular Formula: C₁₈H₁₈N₂O₂
• Molecular Weight: 294.353
• Mol file: 1427475-97-5.mol

Synonyms:1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole

Chemical Property of 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole

There total 4 articles about 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C14H14ClN2(1+)*CF3O3S(1-) + p-aminoethylbenzoate (94-09-7) → 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole (1427475-97-5)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2016.08.040

Reference yield: 69.0%

2-phenyl-2-imidazoline (936-49-2) + 4-iodobenzoic acid ethyl ester (51934-41-9) → 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole (1427475-97-5)

Guidance literature:

With caesium carbonate; copper(I) bromide; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 18h; Inert atmosphere; Molecular sieve;

DOI:10.1021/jo400120r

Reference yield:

benzoyl chloride (98-88-4) → 1-(4-benzoic acid ethyl ester)-2-phenyl-4,5-dihydro-1H-imidazole (1427475-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 h / Inert atmosphere

2: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: dichloromethane / 20 °C / Inert atmosphere

With triethylamine; In dichloromethane;

DOI:10.1016/j.tet.2016.08.040

upstream raw materials:

2-phenyl-2-imidazoline

4-iodobenzoic acid ethyl ester

p-aminoethylbenzoate

benzoyl chloride