Ethyl 5-hydroxy-5-phenylpentanoate

Base Information

• Chemical Name: Ethyl 5-hydroxy-5-phenylpentanoate
• CAS No.: 139527-18-7
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 139527-18-7.mol

Synonyms:Ethyl 5-hydroxy-5-phenylpentanoate

Chemical Property of Ethyl 5-hydroxy-5-phenylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Ethyl 5-hydroxy-5-phenylpentanoate

There total 12 articles about Ethyl 5-hydroxy-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

ethyl 4-benzoylbutanoate (73172-56-2) → Ethyl 5-hydroxy-5-phenylpentanoate (139527-18-7)

Guidance literature:

With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at -25 ℃; for 12h;

DOI:10.1021/jo025594y

Reference yield: 49.0%

5-Hydroxy-5-phenyl-pentanoic acid ethyl ester (94800-94-9) → (R)-ethyl 5-hydroxy-5-phenylpentanoate (94800-94-9,139527-18-7) + 1-phenyl-(1S)-pentane-1,5-diol

Guidance literature:

With C₅₀H₆₃ClIrN₂P; potassium tert-butylate; hydrogen; In ethanol; at 25 - 30 ℃; for 0.5h; under 7600.51 Torr; enantioselective reaction; Autoclave; Green chemistry;

DOI:10.1021/ja510990v

Reference yield:

ethyl 4-benzoylbutanoate (73172-56-2) → (R)-ethyl 5-hydroxy-5-phenylpentanoate (94800-94-9,139527-18-7)

Guidance literature:

With glucose dehydrogenase; β-D-glucose; In aq. buffer; pH=7.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1021/cs4010024

upstream raw materials:

benzaldehyde

ethyl 4-benzoylbutanoate

5-Hydroxy-5-phenyl-pentanoic acid ethyl ester

phenylmagnesium bromide

Downstream raw materials:

(6S) 6-phenyltetrahydro-2H-pyran-2-one