1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

Base Information

Chemical Name:1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one
CAS No.:73931-23-4
Molecular Formula:C₂₃H₂₄F₂N₂O
Molecular Weight:382.453
Hs Code.:

Synonyms:1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

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Chemical Property of 1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

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Technology Process of 1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

There total 5 articles about 1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 7065-46-5
3,3-dimethylbutanoic acid chloride

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 73931-23-4
1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00180a011

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 73931-23-4
1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / ethanol / 1.75 h / Heating

2: 78 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

3: 41 percent / KOH, water / ethanol / 23 h / Heating

4: 77 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With potassium hydroxide; water; sodium carbonate; triethylamine; copper(I) bromide; In ethanol; dichloromethane;
DOI:10.1021/jm00180a011

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 73931-23-4
1-[8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-3,3-dimethyl-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / ethanol / 1.75 h / Heating

2: 78 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

3: 41 percent / KOH, water / ethanol / 23 h / Heating

4: 77 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With potassium hydroxide; water; sodium carbonate; triethylamine; copper(I) bromide; In ethanol; dichloromethane;
DOI:10.1021/jm00180a011