2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

Base Information

Chemical Name:2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide
CAS No.:1393843-20-3
Molecular Formula:C₂₃H₁₈ClFN₄O₂S
Molecular Weight:468.939
Hs Code.:

Synonyms:2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

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Chemical Property of 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

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Technology Process of 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

There total 5 articles about 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1603-91-4
4-methylthiazol-2-ylamine

: 1393843-91-8
2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxylic acid

: 1393843-20-3
2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

Guidance literature:: 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

4-methylthiazol-2-ylamine; In tetrahydrofuran; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.03.068

Reference yield:

: 1393843-93-0
ethyl 2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxylate

: 1393843-20-3
2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; water / 24 h / 10 - 15 °C

2.1: 4-methyl-morpholine / dichloromethane; tetrahydrofuran / 0.5 h / 20 °C

2.2: 12 h / 60 °C

With 4-methyl-morpholine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 934388-20-2
ethyl 4-acetyl-3-hydroxybenzoate

: 1393843-20-3
2-(2-chloro-6-fluorophenyl)-4,4-dimethyl-N-(4-methylthiazol-2-yl)-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyrrolidine / methanol / Reflux

2.1: isopentyl nitrite; hydrogenchloride / ethanol; water / 20 °C

3.1: acetic acid; ammonium acetate / 100 °C

4.1: sodium hydroxide / ethanol; water / 12 h / 10 - 20 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.2: 8 h / 20 °C / Inert atmosphere

With pyrrolidine; hydrogenchloride; ammonium acetate; chloroformic acid ethyl ester; acetic acid; triethylamine; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1016/j.bmcl.2017.03.068