Technology Process of 2-amino-4-oxo-5-vinyl-7-(3',4'-dimethoxybenzyl)-3,4,5,6-tetrahydropyrrolo[2,3-d]pyrimidine
There total 12 articles about 2-amino-4-oxo-5-vinyl-7-(3',4'-dimethoxybenzyl)-3,4,5,6-tetrahydropyrrolo[2,3-d]pyrimidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
guanidine hydrochloride;
With
sodium methylate;
In
methanol;
at 20 ℃;
for 0.5h;
1-(3',4'-dimethoxybenzyl)-3-methoxycarbonyl-4-vinyl-2-pyrrolidinethione;
In
methanol;
at 90 ℃;
for 1h;
under 15 Torr;
Further stages.;
DOI:10.1021/jo001580l
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 95 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C
2.1: 90 percent / KOH; N2H4*H2O / ethane-1,2-diol / 110 °C
3.1: 87 percent / Et3N; DMAP / ethyl acetate / 0 - 20 °C
4.1: 86 percent / Mn(OAc)3*2H2O; Cu(OAc)2*H2O / acetic acid / 20 °C
5.1: 85 percent / P4S10 / tetrahydrofuran / Heating
6.1: NaOMe / methanol / 0.5 h / 20 °C
6.2: 68 percent / methanol / 1 h / 90 °C / 15 Torr
With
dmap; potassium hydroxide; tetraphosphorus decasulfide; copper diacetate; sodium methylate; manganese triacetate; tetra-(n-butyl)ammonium iodide; sodium hydride; hydrazine hydrate; triethylamine;
In
tetrahydrofuran; methanol; ethylene glycol; acetic acid; ethyl acetate;
DOI:10.1021/jo001580l
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 85 percent / P4S10 / tetrahydrofuran / Heating
2.1: NaOMe / methanol / 0.5 h / 20 °C
2.2: 68 percent / methanol / 1 h / 90 °C / 15 Torr
With
tetraphosphorus decasulfide; sodium methylate;
In
tetrahydrofuran; methanol;
DOI:10.1021/jo001580l
