N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide

Base Information

• Chemical Name: N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide
• CAS No.: 145936-41-0
• Molecular Formula: C₁₉H₂₂N₆O₄
• Molecular Weight: 398.421

Synonyms:N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide

Chemical Property of N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide

Chemical Property:

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Technology Process of N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide

There total 3 articles about N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formic acid (64-18-6) + 2,4-diamino-5-methyl-6[[(3,4,5-trimethoxyphenyl)amino]methyl]pyrido[2,3-d]pyrimidine (145936-38-5) → N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide (145936-41-0)

Guidance literature:

In water; for 5h; Ambient temperature;

DOI:10.1021/jm00074a026

Reference yield:

2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carbonitrile (101810-73-5) → N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide (145936-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 19 percent / H₂, 70percent aq. AcOH / Raney nickel / 24 h / 760 Torr

2: 93 percent / H₂O / 5 h / Ambient temperature

With hydrogen; acetic acid; nickel; In water;

DOI:10.1021/jm00074a026

Reference yield:

3,4,5-Trimethoxyaniline (24313-88-0) → N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide (145936-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 19 percent / H₂, 70percent aq. AcOH / Raney nickel / 24 h / 760 Torr

2: 93 percent / H₂O / 5 h / Ambient temperature

With hydrogen; acetic acid; nickel; In water;

DOI:10.1021/jm00074a026

upstream raw materials:

formic acid

2,4-diamino-5-methyl-6[[(3,4,5-trimethoxyphenyl)amino]methyl]pyrido[2,3-d]pyrimidine

2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carbonitrile

3,4,5-Trimethoxyaniline

Downstream raw materials:

N-(2,4-Diamino-5-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide

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