4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

Base Information

Chemical Name:4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine
CAS No.:160905-68-0
Molecular Formula:C₆₃H₆₁FN₄O₈Si
Molecular Weight:1049.28
Hs Code.:

Synonyms:4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

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Chemical Property of 4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

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Technology Process of 4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

There total 10 articles about 4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 42506-03-6
pixyl chloride

: 160905-74-8
4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>cytidine

: 160905-68-0
4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

Guidance literature:: With pyridine; Ambient temperature;

Reference yield:

: 98-88-4
benzoyl chloride

: 160905-68-0
4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pyridine / 1) room temperature, 30 min; 2) 90 min, room temperature

2: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

3: 74.5 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

4: 94.7 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.13 h / Ambient temperature

5: 96.8 percent / imidazole / dimethylformamide / Ambient temperature

6: 95.2 percent / pyridine / Ambient temperature

With pyridine; 1H-imidazole; mesitylene sulfonic acid; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 115012-52-7
1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine

: 160905-68-0
4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 74.5 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

2: 94.7 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.13 h / Ambient temperature

3: 96.8 percent / imidazole / dimethylformamide / Ambient temperature

4: 95.2 percent / pyridine / Ambient temperature

With pyridine; 1H-imidazole; mesitylene sulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;