2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

Base Information

Chemical Name:2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide
CAS No.:1345961-26-3
Molecular Formula:C₂₁H₂₂F₃IN₂O
Molecular Weight:502.318
Hs Code.:

Synonyms:2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

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Chemical Property of 2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

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Technology Process of 2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

There total 4 articles about 2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1345961-25-2
2-iodo-N-[(S)-{(S)-1-piperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

: 1345961-26-3
2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2011.09.010

Reference yield:

: (S)-{(S)-1-allylpiperidin-2-yl}(phenyl)methanamine

: 1345961-26-3
2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 2 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / acetonitrile / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; sodium tris(acetoxy)borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.09.010

Reference yield:

: 766473-89-6
3-(trifluoromethyl)-2-iodobenzoic acids

: 1345961-26-3
2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 2 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / acetonitrile / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; sodium tris(acetoxy)borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.09.010