2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

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Chemical Name:2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester
CAS No.:945635-10-9
Molecular Formula:C₃₈H₅₆Cl₃NO₄Si₂
Molecular Weight:753.397
Hs Code.:

2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

Synonyms:2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

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Chemical Property of 2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

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Technology Process of 2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

There total 6 articles about 2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 945635-02-9
C₂₄H₃₁NOSi

: 361434-14-2
(tert-butyl)(3-(iodomethyl)but-3-enyl)(dimethyl)silane

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 945635-10-9
2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: (tert-butyl)(3-(iodomethyl)but-3-enyl)(dimethyl)silane; With zinc; In tetrahydrofuran; at 25 ℃; for 0.333333h;

C₂₄H₃₁NOSi; 2,2,2-Trichloroethyl chloroformate; In tetrahydrofuran; at -78 - 20 ℃; for 18h; Further stages.;
DOI:10.1021/jo070732a

Reference yield:

: 1026307-80-1
C₂₈H₃₇NO₄Si

: 945635-10-9
2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazole / Pd(PPh₃)4 / CH₂Cl₂

2.1: Zn / tetrahydrofuran / 0.33 h / 25 °C

2.2: 37 percent / tetrahydrofuran / 18 h / -78 - 20 °C

With 1,2,3-Benzotriazole; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo070732a

Reference yield:

: 945635-00-7
(R)-4-[tert-butyl(diphenyl)silanyloxy]pyrrolidin-2-one

: 945635-10-9
2-(but-3-enyl)-2-[4-(tert-butyl(dimethyl)silanyloxy)-2-methylidenebutyl]-(R)-4-(tert-butyl(diphenyl)silanyloxy)pyrrolidine-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 56 percent / DMAP; Et₃N / acetonitrile

2.1: Mg / tetrahydrofuran / 1.33 h / 25 °C

2.2: 15 percent / TMEDA / tetrahydrofuran / -78 °C

3.1: benzotriazole / Pd(PPh₃)4 / CH₂Cl₂

4.1: Zn / tetrahydrofuran / 0.33 h / 25 °C

4.2: 37 percent / tetrahydrofuran / 18 h / -78 - 20 °C

With dmap; 1,2,3-Benzotriazole; magnesium; triethylamine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo070732a