methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

Base Information

Chemical Name:methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide
CAS No.:1197856-17-9
Molecular Formula:C₂₈H₂₃F₃N₂O₅S
Molecular Weight:556.562
Hs Code.:

methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

Synonyms:methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

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Chemical Property of methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

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Technology Process of methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

There total 8 articles about methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1197856-12-4
methyl 7-(naphthalen-1-ylmethyl)-8-(3-(trifluoromethyl)phenyl)-1,1,5-trioxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

: 74-89-5
methylamine

: 1197856-17-9
methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

Guidance literature:: methyl 7-(naphthalen-1-ylmethyl)-8-(3-(trifluoromethyl)phenyl)-1,1,5-trioxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate; methylamine; With sodium methylate; In methanol; at 0 - 20 ℃; for 15.1667h; Inert atmosphere;

With pyridine; bromine; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol9023024

Reference yield: 28.99%

: methyl 7-(naphthalen-1-ylmethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylate 1,1-dioxide

: 74-89-5
methylamine

: 1197856-17-9
methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

Guidance literature:: methyl 7-(naphthalen-1-ylmethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylate 1,1-dioxide; methylamine; With sodium methylate; In methanol; at 0 - 20 ℃; for 16h;

With pyridine; bromine; In acetonitrile; at 0 ℃; for 1h;

Reference yield:

: 1024869-14-4
C₁₁H₁₂F₃NO

: 1197856-17-9
methyl 2-methyl-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

1.2: 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 16 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

4.1: sodium methylate / methanol / 16 h / 0 - 20 °C

4.2: 1 h / 0 °C

With sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane;