diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 1424371-11-8
• Molecular Formula: C₂₈H₂₆Cl₂N₂O₅
• Molecular Weight: 541.431
• Mol file: 1424371-11-8.mol

Synonyms:diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 4 articles about diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,4,7-trichloroquinoline (1677-49-2) + 4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (10354-30-0) → diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1424371-11-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 48h; regioselective reaction;

DOI:10.1007/s11164-013-1085-4

Reference yield:

3-chloro-aniline (108-42-9) → diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1424371-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1007/s11164-013-1085-4

Reference yield:

ethyl acetoacetate (141-97-9) → diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1424371-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / ethanol

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With ammonium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: |Hantzsch Dihydropyridine Synthesis;

DOI:10.1007/s11164-013-1085-4

upstream raw materials:

2,4,7-trichloroquinoline

4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

3-chloro-aniline

ethyl acetoacetate