1677-49-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2,4,7-Trichloroquinoline is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural properties and reactivity. Its presence in these compounds can enhance their efficacy and performance in treating diseases and controlling pests.
Used in Fluorescent Dye Applications:
2,4,7-Trichloroquinoline is employed as a fluorescent dye in biological and environmental applications. Its fluorescent properties allow for the visualization and tracking of specific molecules or processes, making it a valuable tool in research and diagnostics.
Used in Research and Diagnostics:
In the field of research and diagnostics, 2,4,7-trichloroquinoline is used as a fluorescent marker for the detection and analysis of various biological molecules and environmental contaminants. Its ability to emit fluorescence upon exposure to specific wavelengths of light aids in the identification and quantification of target substances.
Safety Considerations:

InChI:InChI=1/C9H4Cl3N/c10-5-1-2-6-7(11)4-9(12)13-8(6)3-5/h1-4H

Upstream product

• 1677-35-6 7-chloroquinoline-2,4-diol 
• 98994-41-3 4,7-dichloro-1-methyl-1H-quinolin-2-one 
• 141-82-2 malonic acid 
• 108-42-9 3-chloro-aniline 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 412336-41-5 2-(2-ethoxycarbonyl-acetylamino)-4-chloro-benzoic acid methyl ester 
• 1077-74-3 4,7-dichloroquinoline 1-oxide 
• 5900-56-1 2-acetylamino-4-chlorobenzoic acid 
• 5900-55-0 N-(5-chloro-2-methylphenyl)acetamide 
• 89-59-8 4-chloro-2-nitrotoluene 
• 95-79-4 5-chloro-2-methyl-benzenamine 

Downstream Products

• 1386328-66-0 ethyl 4-(3-(2,7-dichloroquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1424371-21-0 dimethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1424371-11-8 diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Regioselective synthesis of 2-chloroquinoline based ethyl 4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and their In-Silico evaluation against P. Falciparum lactate dehydrogenase

The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.

Regioselective synthesis of novel 2-chloroquinoline derivatives of 1,4-dihydropyridines

Highly regioselective reaction of some substituted 2,4-dichloroquinolines with symmetrical 1,4-dihydropyridines, leading to novel quinoline derivatives of DHPs, has been achieved in the presence of powdered K2CO 3, as a mild and efficient base, at moderate temperature. All the synthesized compounds were characterized by use of IR, NMR, and mass spectral data.

Ultrasound-promoted synthesis of novel 2-chloroquinolin-4-pyrimidine carboxylate derivatives as potential antibacterial agents

Ultrasound-promoted reaction of substituted 2,4-dichloroquinolines (1) with ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5- carboxylate (2) in the presence of K2CO3 as mild base at moderate temperatures leads

SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS

The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b), enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated

2,4-Dihalogenoquinolines. Synthesis, Orientation Effects and 1H and 13C NMR Spectral Studies

Isomer ratios for the syntheses of 2,4-dichloroquinolines from meta-substituted and 3,4-disubstituted anilines are reported, a synthesis of 2,4-dibromoquinoline 1b is also described.The structures of certain bromination products 17 and 1f obtained from 4-hydroxy-2-quinolone have been revised.A thorough study of the 1H and 13C NMR spectra of a series of 2,4-dihalogenoquinolines is presented and the effects of the halogen substituents on JCH couplings are highlighted.