1677-49-2

Basic information

• Product Name: 2,4,7-trichloroquinoline
• Synonyms: 2,4,7-trichloroquinoline;Quinoline, 2,4,7-trichloro-;NSC 131496
• CAS NO: 1677-49-2
• Molecular Formula: C9H4Cl3N
• Molecular Weight: 232.49376
• Mol File: 1677-49-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 106.5-107.5℃
• Boiling Point: 321.4°Cat760mmHg
• Flash Point: 177.8°C
• Appearance: /
• Density: 1.523±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000561mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.69±0.50(Predicted)
• CAS DataBase Reference: 2,4,7-trichloroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,7-trichloroquinoline(1677-49-2)
• EPA Substance Registry System: 2,4,7-trichloroquinoline(1677-49-2)

Safety Data

• Hazardous Substances Data: 1677-49-2(Hazardous Substances Data)

Usage

General Description

2,4,7-trichloroquinoline is a chemical compound that contains three chlorine atoms attached to a quinoline ring structure. It is a halogenated aromatic compound and has a molecular formula of C9H4Cl3N. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its unique structural properties and reactivity. It has also been investigated for its potential use as a fluorescent dye in biological and environmental applications. Additionally, 2,4,7-trichloroquinoline is known to have moderate toxicity and should be handled and used with caution in laboratory and industrial settings.

InChI:InChI=1/C9H4Cl3N/c10-5-1-2-6-7(11)4-9(12)13-8(6)3-5/h1-4H

Upstream product

• 141-82-2 malonic acid 
• 108-42-9 3-chloro-aniline 
• 1077-74-3 4,7-dichloroquinoline 1-oxide 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 1677-35-6 7-chloroquinoline-2,4-diol 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 5900-56-1 2-acetylamino-4-chlorobenzoic acid 
• 412336-41-5 2-(2-ethoxycarbonyl-acetylamino)-4-chloro-benzoic acid methyl ester 
• 5900-55-0 N-(5-chloro-2-methylphenyl)acetamide 
• 89-59-8 4-chloro-2-nitrotoluene 
• 98994-41-3 4,7-dichloro-1-methyl-1H-quinolin-2-one 

Downstream Products

• 1386328-66-0 ethyl 4-(3-(2,7-dichloroquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1424371-11-8 diethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1424371-21-0 dimethyl 4-(4-(2,7-dichloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

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Regioselective synthesis of novel 2-chloroquinoline derivatives of 1,4-dihydropyridines

Highly regioselective reaction of some substituted 2,4-dichloroquinolines with symmetrical 1,4-dihydropyridines, leading to novel quinoline derivatives of DHPs, has been achieved in the presence of powdered K2CO 3, as a mild and efficient base, at moderate temperature. All the synthesized compounds were characterized by use of IR, NMR, and mass spectral data.

SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS

The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b), enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated