2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Base Information

Chemical Name:2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide
CAS No.:1256779-99-3
Molecular Formula:C₃₅H₄₂N₄O₃
Molecular Weight:566.743
Hs Code.:

Synonyms:2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Suppliers and Price of 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

There total 8 articles about 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.2%

: 1256779-53-9
2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetic acid

: 1256779-99-3
2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Guidance literature:: 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

With ammonium hydroxide; In dichloromethane; water; at 20 ℃; for 4h;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256779-99-3
2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 12 h / Reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

6.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

7.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

8.2: 4 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; tetrabutyl ammonium fluoride; water; trimethylaluminum; phosphorus tribromide; sodium hydride; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; n-heptane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256779-99-3
2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetoamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 12 h / Reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

5.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

6.2: 4 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; tetrabutyl ammonium fluoride; water; trimethylaluminum; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; n-heptane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;