N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide

Base Information

Chemical Name:N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide
CAS No.:133229-19-3
Molecular Formula:C₁₈H₂₄N₂O₄S
Molecular Weight:364.466
Hs Code.:
ChEMBL ID:CHEMBL289724
DSSTox Substance ID:DTXSID601147578
Nikkaji Number:J409.722J

Synonyms:CHEMBL289724;SCHEMBL9654030;DTXSID601147578;133229-19-3;N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide

Suppliers and Price of N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:364.14567842
Heavy Atom Count:25
Complexity:452

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)NC1=CC=C(C=C1)OCC(CNCCC2=CC=CC=C2)O

Technology Process of N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide

There total 5 articles about N-[4-[2-Hydroxy-3-[(2-phenylethyl)amino]propoxy]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 133229-19-3
1-(4-methanesulfonamidophenoxy)-3-(N-phenylethylamino)-2-propanol

Guidance literature:: Multi-step reaction with 5 steps

1: 1 N NaOH / 10 h

2: ethanol / 4 h / Heating

3: 72 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

4: 97 percent / H₂, 2 N NaOH / 10percent Pd/c / ethanol / 0.25 h / 760 Torr

5: 2.) 1 N HCl / 1.) ether, from 10 deg C to RT, 12 h, 2.) 1 h

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00109a007

Reference yield:

: 125228-75-3
4-nitrophenyl 2-oxiranylmethyl ether

: 133229-19-3
1-(4-methanesulfonamidophenoxy)-3-(N-phenylethylamino)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 4 h / Heating

2: 72 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

3: 97 percent / H₂, 2 N NaOH / 10percent Pd/c / ethanol / 0.25 h / 760 Torr

4: 2.) 1 N HCl / 1.) ether, from 10 deg C to RT, 12 h, 2.) 1 h

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00109a007

Reference yield:

: 133228-96-3
1-(4-Nitro-phenoxy)-3-phenethylamino-propan-2-ol

: 133229-19-3
1-(4-methanesulfonamidophenoxy)-3-(N-phenylethylamino)-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

2: 97 percent / H₂, 2 N NaOH / 10percent Pd/c / ethanol / 0.25 h / 760 Torr

3: 2.) 1 N HCl / 1.) ether, from 10 deg C to RT, 12 h, 2.) 1 h

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00109a007