methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

Base Information

Chemical Name:methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate
CAS No.:234752-14-8
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

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Chemical Property of methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

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Technology Process of methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

There total 4 articles about methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 554-12-1
propanoic acid methyl ester

: 66854-78-2
(S)-N-(benzyloxycarbonyl)valylimidazolide

: 234752-14-8
methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

Guidance literature:: propanoic acid methyl ester; With lithium diisopropyl amide; In hexane; at -78 ℃; for 0.5h;

(S)-N-(benzyloxycarbonyl)valylimidazolide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.3987/COM-99-8495

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 234752-14-8
methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18 g / NaHCO₃ / H₂O / 20 h / 20 °C

2.1: tetrahydrofuran / 2 h / 20 °C

3.1: LDA / hexane / 0.5 h / -78 °C

3.2: 48 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

With sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; 1.1: Acylation / 2.1: Acylation / 3.1: Acylation / 3.2: Acylation;
DOI:10.3987/COM-99-8495

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 234752-14-8
methyl (3S)-2,5-dimethyl-3-oxo-4-[(N-phenylmethoxycarbonyl)amino]hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: LDA / hexane / 0.5 h / -78 °C

2.2: 48 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.1: Acylation / 2.1: Acylation / 2.2: Acylation;
DOI:10.3987/COM-99-8495