C₄₇H₆₄N₄O₁₂S₃

Base Information

• Chemical Name: C₄₇H₆₄N₄O₁₂S₃
• CAS No.: 91613-41-1
• Molecular Formula: C₄₇H₆₄N₄O₁₂S₃
• Molecular Weight: 973.243
• Mol file: 91613-41-1.mol

Synonyms:C₄₇H₆₄N₄O₁₂S₃

Chemical Property of C₄₇H₆₄N₄O₁₂S₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₆₄N₄O₁₂S₃

There total 2 articles about C₄₇H₆₄N₄O₁₂S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C45H60N4O12S3 → C47H64N4O12S3 (91613-41-1)

Guidance literature:

With sodium cyanoborohydride; In water; acetic acid; acetonitrile; for 1h; Ambient temperature;

DOI:10.1246/bcsj.57.529

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6'-N-(benzyloxycarbonyl)-3',4':5,6-di-O-cyclohexylidene-1,2',3-tri-N-tosylneamine (88985-60-8) → C47H64N4O12S3 (91613-41-1)

Guidance literature:

Multistep reaction;

Reference yield: 83.0%

C47H64N4O12S3 (91613-41-1) → C47H64N4O13S3*H2O

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 1h;

upstream raw materials:

formaldehyd

6'-N-(benzyloxycarbonyl)-3',4':5,6-di-O-cyclohexylidene-1,2',3-tri-N-tosylneamine

Downstream raw materials:

3',4':5,6-di-O-cyclohexylidene-6',6'-di-N-methyl-1,2',3-tri-N-tosylneamine 6'-N-oxide

1-N-acetyl-4-O-<-3',6'-di-O-acetyl-4',8'-anhydro-2',7'-dideoxy-2'-(tosylamino)-D-glycero-α-D-gluco-oct-7'-enopyranos-1'-yl>-5,6-O-cyclohexylidene-1,3-di-N-tosyl-2-deoxystreptamine

4-O-<3',4'-O-cyclohexylidene-2'-deoxy-(tosylamino)-α-D-gluco-hexodialdo-1',5'-pyranosyl>-5,6-O-cyclohexylidene-1,3-di-N-tosyl-2-deoxystreptamine

1-N-acetyl-4-O-<(8'R)-3',6',8'-tri-O-acetyl-2',7'-dideoxy-2'-(tosylamino)-L-glycero-α-D-gluco-octodialdo-1',5':8',4'-dipyranos-1'-yl>-5,6-O-cyclohexylidene-1,3-di-N-tosyl-2-deoxystreptamine

Refernces

• 1、 Tatsuta, Kuniaki,Akimoto, Kohji,Takahashi, Hideaki,Hamatsu, Takao. "TOTAL SYNTHESIS OF APRAMYCIN". . p. 4867 - 4870. Retrieved 2007/10/02.