tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

Base Information

Chemical Name:tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate
CAS No.:1268526-85-7
Molecular Formula:C₁₈H₃₀ClNO₃Si
Molecular Weight:371.98
Hs Code.:

Synonyms:tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

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Chemical Property of tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

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Technology Process of tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

There total 1 articles about tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1186638-59-4
5-((tert-butyldimethylsilyloxy)methyl)-2-chloroaniline

: 1268526-85-7
tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

Guidance literature:: 5-((tert-butyldimethylsilyloxy)methyl)-2-chloroaniline; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1268526-85-7
tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

: 73183-34-3
bis(pinacol)diborane

: 1186638-29-8
tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate

Guidance literature:: With potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 110 ℃; Inert atmosphere;

Reference yield:

: 1268526-85-7
tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-chlorophenylcarbamate

: 1258595-24-2
(E)-(2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-1-fluorovinyl)phosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 110 °C / Inert atmosphere

2.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

6.1: lithium diisopropyl amide / hexane; pentane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 - 20 °C

6.2: -78 - 20 °C

7.1: trimethylsilyl bromide / dichloromethane / 2 h / 0 - 20 °C

With potassium phosphate; trimethylsilyl bromide; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; lithium diisopropyl amide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; ethylbenzene; water; dimethyl sulfoxide; pentane; butan-1-ol;