5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

Base Information

Chemical Name:5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde
CAS No.:1186635-72-2
Molecular Formula:C₂₃H₂₁N₃O₂
Molecular Weight:371.439
Hs Code.:

Synonyms:5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

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Chemical Property of 5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

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Technology Process of 5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

There total 10 articles about 5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1186636-13-4
(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)methanol

: 1186635-72-2
5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2.5h;
DOI:10.1021/acs.jmedchem.6b00489

Reference yield:

: 85331-33-5
2-Cyano-3,5-dichloropyridine

: 1186635-72-2
5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

With potassium phosphate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1186637-69-3
3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile

: 1186635-72-2
5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

With potassium phosphate; tetrabutyl ammonium fluoride; hydrogen; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; butan-1-ol;