(R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

Base Information

Chemical Name:(R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one
CAS No.:1242985-31-4
Molecular Formula:C₂₁H₂₀BrNO₃
Molecular Weight:414.299
Hs Code.:

Synonyms:(R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

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Technology Process of (R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

There total 3 articles about (R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5468-52-0,67942-91-0,87068-75-5,4385-97-1
N-benzoyl-2-aminobutyric acid

: 20511-04-0,3815-31-4
(E)-4-(4-bromophenyl)but-3-ene-2-one

: 1242985-31-4
(R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

Guidance literature:: With FBIP-Cl; sodium acetate; silver trifluoromethanesulfonate; acetic anhydride; acetic acid; at 8 - 30 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja106088v

Reference yield:

: 20511-04-0,3815-31-4
(E)-4-(4-bromophenyl)but-3-ene-2-one

: 93-97-0
benzoic acid anhydride

: 2835-81-6
2-aminobutanoic acid

: 1242985-31-4
(R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

: (S)-4-((S)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

Guidance literature:: With FBIP-OTf; sodium acetate; benzoic acid; In tetrahydrofuran; toluene; at 70 ℃; for 7h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201200085

Reference yield:

: 98-88-4
benzoyl chloride

: 1242985-31-4
(R)-4-((R)-1-(4-bromophenyl)-3-oxobutyl)-4-ethyl-2-phenyloxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; acetonitrile / 0 - 20 °C

2: FBIP-OTf; sodium acetate / acetic acid; acetic anhydride / 23 h / 30 °C / Inert atmosphere

With FBIP-OTf; sodium acetate; sodium hydroxide; In water; acetic anhydride; acetic acid; acetonitrile; 2: |Michael Addition;
DOI:10.1002/chem.201202455