ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

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Chemical Name:ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate
CAS No.:937055-25-9
Molecular Formula:C₂₈H₂₉ClN₄O₅
Molecular Weight:537.015
Hs Code.:

Synonyms:ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

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Chemical Property of ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

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Technology Process of ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

There total 9 articles about ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23159-61-7
ethyl (1H-1,2,4-triazol-3-yl)acetate

: 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate

: 937055-25-9
ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

: 937055-24-8
ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-5-yl)acetate

Guidance literature:: ethyl (1H-1,2,4-triazol-3-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 937057-52-8
methyl (E)-3-(1-{4-chloro-2-[(2,3-dimethoxyphenyl)(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

: 937055-25-9
ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

: 937055-24-8
ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: Resolution of racemate

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

3.2: 3 h / 0 °C

4.1: triethylamine / dichloromethane / 3 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 80 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 937057-51-7
methyl (E)-3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-2-propenoate

: 937055-25-9
ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate

: 937055-24-8
ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: Resolution of racemate

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

4.2: 3 h / 0 °C

5.1: triethylamine / dichloromethane / 3 h / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 80 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;