23159-61-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 1H-1,2,4-triazol-5-ylacetate is used as an active pharmaceutical ingredient for the development of new drugs due to its antifungal and antibacterial properties. It aids in the treatment of various infections caused by fungi and bacteria.
Used in Agricultural Industry:
Ethyl 1H-1,2,4-triazol-5-ylacetate is used as a key component in the formulation of pesticides. Its antifungal and antibacterial properties help protect crops from diseases and pests, ensuring a healthy and productive agricultural yield.
Used in Chemical Research and Development:
Ethyl 1H-1,2,4-triazol-5-ylacetate is used as a versatile building block in the synthesis of other organic compounds. Its reactivity makes it an important tool for chemical research and development, contributing to the creation of new and innovative chemical products.
Safety Precautions:
It is important to handle Ethyl 1H-1,2,4-triazol-5-ylacetate with care and follow safety protocols, as it can be hazardous if not handled properly. Proper protective equipment and handling procedures should be followed to minimize risks associated with its use.

InChI:InChI=1/C6H9N3O2/c1-2-11-6(10)3-5-7-4-8-9-5/h4H,2-3H2,1H3,(H,7,8,9)

Upstream product

• 64007-56-3 (5-thioxo-2,5-dihydro-1H-[1,2,4]triazol-3-yl)-acetic acid ethyl ester 
• 227958-74-9 ethyl 3-[2-(aminocarbonothioyl)hydrazino]-3-oxopropanoate 
• 64007-56-3 ethyl (5-mercapto-1H-1,2,4-triazol-3-yl)acetate 
• 1001924-20-4 ethoxycarbonyl-N-formyl-acetamidrazone 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 
• 624-84-0 formic acid hydrazide 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 155049-60-8 (1H-1,2,4-triazol-3-yl)acetic acid 
• 937054-47-2 Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate 
• 937054-46-1 ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-5-yl)acetate 
• 937055-25-9 ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate 
• 937055-24-8 ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-5-yl)acetate 

Relevant academic research and scientific papers

Synthesis of α-substituted 2-(1H-1,2,4-triazol-3-yl)acetates and 5-amino-2,4-dihydro-3H-pyrazol-3-ones via the Pinner strategy

A series of 2-(1H-1,2,4-triazol-3-yl)acetates, as well as 4-mono- and 4,4-disubstituted 5-amino-2,4-dihydro-3H-pyrazol-3-ones (including spirocyclic derivatives) have been synthesized using the Pinner reaction strategy. α-Mono- and α,α-disubstituted ethyl cyanoacetates were converted into the corresponding carboxyimidate salts that served as the key intermediates. Their further reaction with formylhydrazide or hydrazine hydrate provided triazolylacetates or aminopyrazolones (including spirocyclic derivatives), depending on the structure of the starting Pinner salt and the nature of the nucleophile. The scope and limitations of the developed synthetic method have been established.

Discovery of novel, highly potent, and selective matrix metalloproteinase (MMP)-13 inhibitors with a 1,2,4-triazol-3-yl moiety as a zinc binding group using a structure-based design approach

On the basis of a superposition study of X-ray crystal structures of complexes of quinazoline derivative 1 and triazole derivative 2 with matrix metalloproteinase (MMP)-13 catalytic domain, a novel series of fused pyrimidine compounds which possess a 1,2,4-triazol-3-yl group as a zinc binding group (ZBG) was designed. Among the herein described and evaluated compounds, 31f exhibited excellent potency for MMP-13 (IC50 = 0.036 nM) and selectivities (greater than 1,500-fold) over other MMPs (MMP-1, -2, -3, -7, -8, -9, -10, and -14) and tumor necrosis factor-α converting enzyme (TACE). Furthermore, the inhibitor was shown to protect bovine nasal cartilage explants against degradation induced by interleukin-1 and oncostatin M. In this article, we report the discovery of extremely potent, highly selective, and orally bioavailable fused pyrimidine derivatives that possess a 1,2,4-triazol-3-yl group as a novel ZBG for selective MMP-13 inhibition.

Design and chemical synthesis of [1,2,4]triazol[1,5-c]pyrimidin-5-yl amines, a novel class of VEGFR-2 kinase inhibitors

The Letter describes a facile approach to 7,8-dihydro[1,2,4]triazol[1,5-c]pyrimidin-5-yl amines, a novel class of potent inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). The synthetic sequence is centered around preparation of the k

HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF

The present invention provides a novel amide compound represented by the following formula, which has a matrix metalloproteinase inhibitory activity and is useful as a pharmaceutical agent. wherein each symbol is as defined in the specification.