2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene

Base Information

• Chemical Name: 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene
• CAS No.: 849346-90-3
• Molecular Formula: C₁₆H₁₄O₂S₂
• Molecular Weight: 302.418
• Mol file: 849346-90-3.mol

Synonyms:2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene

Chemical Property of 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene

Chemical Property:

Purity/Quality:

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Technology Process of 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene

There total 1 articles about 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

thiophene-2-carbaldehyde (98-03-3) + 2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene (596104-73-3) → 2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene (849346-90-3)

Guidance literature:

2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; for 0.5h;

thiophene-2-carbaldehyde; In tetrahydrofuran; hexane; at 0 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;

DOI:10.1016/j.bmc.2004.12.048

Reference yield: 11.0%

2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene (849346-90-3) + 2,5-bis[1-(4-methoxyphenyl)-1-pyrrolomethyl]thiophene (398514-79-9) → 5-phenyl-20-(2-thienyl)-10,15-bis(4-methoxyphenyl)-21,23-dithiaporphyrin

Guidance literature:

With boron trifluoride diethyl etherate; chloranil; In dichloromethane; for 0.5h;

DOI:10.1016/j.bmc.2004.12.048

Reference yield:

2-[hydroxy(phenyl)methyl]-5-[hydroxy(2-thienyl)methyl]thiophene (849346-90-3) → 5-phenyl-20-(2-thienyl)-10,15-bis(4-hydroxyphenyl)-21,23-dithiaporphyrin

Guidance literature:

Multi-step reaction with 2 steps

1: 11 percent / 2,3,5,6-tetrachlorobenzoquinone; BF₃*OEt₂ / CH₂Cl₂ / 0.5 h

2: 94 percent / BBr₃ / CH₂Cl₂ / 5 h

With boron trifluoride diethyl etherate; boron tribromide; chloranil; In dichloromethane;

DOI:10.1016/j.bmc.2004.12.048

upstream raw materials:

thiophene-2-carbaldehyde

2-[1-phenyl-1-(tert-butyldimethylsilyloxy)methyl]thiophene