N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

Base Information

Chemical Name:N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide
CAS No.:1069093-33-9
Molecular Formula:C₁₆H₁₆ClF₂N₅O₂
Molecular Weight:383.785
Hs Code.:

Synonyms:N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

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Chemical Property of N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

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Technology Process of N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

There total 7 articles about N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 25676-75-9
4-bromo-1-methyl-1H-imidazole

: 1069093-12-4
N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-2-oxo-4-imidazolidinecarboxamide

: 1069093-33-9
N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: With potassium phosphate; copper(l) iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine; In 1,4-dioxane; for 1h; Heating / reflux;

Reference yield:

: 845543-46-6
(S)-1-benzyl 4-tert-butyl 3-methyl-2-oxoimidazolidine-1,4-dicarboxylate

: 1069093-33-9
N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C

3.2: 18 h / 20 °C

4.1: potassium phosphate; copper(l) iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine / 1,4-dioxane / 1 h / Heating / reflux

With N-ethylmorpholine;; potassium phosphate; copper(l) iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 98649-15-1
1‐benzyl 4‐methyl 3‐methyl‐2‐oxoimidazolidine‐1,4‐dicarboxylate

: 1069093-33-9
N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-imidazol-4-yl)-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 22 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 5 h / 0 °C

2.2: pH 1

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C

3.2: 18 h / 20 °C

4.1: potassium phosphate; copper(l) iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine / 1,4-dioxane / 1 h / Heating / reflux

With N-ethylmorpholine;; lithium hydroxide; potassium phosphate; copper(l) iodide; trans-N,N-dimethyl-cyclohexane-1,2-diamine; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;