98649-15-1Relevant articles and documents
IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS
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Page/Page column 41-42, (2008/12/04)
The present invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders / diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.
Heterocyclic Prostaglandins. VI. Synthesis of 11-Deoxy-8,10-diazaprostaglandin E1 and Its 10-Methyl Derivative
Saijo, Shigeyoshi,Wada, Masao,Himizu, Jun-ichi,Ishida, Akihiko
, p. 1459 - 1467 (2007/10/02)
The synthesis of 11-deoxy-8,10-diazaprostaglandin E1 (1a) starting from methyl 3-benzyloxycarbonyl-2-oxo-4-imidazolidinecarboxylate (3a) is reported.Alkylation of 3a with methyl 7-bromoheptanoate and NaH gave methyl 1-benzyloxycarbonyl-3-(6-met