4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid

Base Information

• Chemical Name: 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid
• CAS No.: 816430-11-2
• Molecular Formula: C₂₄H₂₈N₂O₇S
• Molecular Weight: 488.562
• Mol file: 816430-11-2.mol

Synonyms:4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid

Chemical Property of 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid

There total 1 articles about 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-((2-aminoethyl)-amino)-naphtalene-1-sulfonic acid (50402-56-7) + 4-(4-formyl-3-methoxy-phenoxy)-butyric acid (309964-23-6) → 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid (816430-11-2)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In methanol; water; pH=4;

DOI:10.1016/j.tetlet.2004.11.026

Reference yield: 76.0%

Fmoc-(tBu)Asp-OH (71989-14-5) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) + 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid (816430-11-2) → 4-{3-carboxy-2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-propionylamino}-4-{1-[2-carboxy-1-(1-{4-guanidino-1-[2-(5-sulfo-naphthalen-1-ylamino)-ethylcarbamoyl]-butylcarbamoyl}-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-butyric acid

Guidance literature:

Multistep reaction;

DOI:10.1016/j.tetlet.2004.11.026

Reference yield: 63.0%

Fmoc-Pro-OH (71989-31-6) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + 2,5-dioxo-1-pyrrolidinyl 4-[(1E)-2-[4-(dimethylamino)phenyl]diazenyl]-benzoate (1155356-49-2) + 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid (816430-11-2) → C72H85N13O18S

Guidance literature:

DOI:10.1016/j.tetlet.2004.11.026

upstream raw materials:

5-((2-aminoethyl)-amino)-naphtalene-1-sulfonic acid

4-(4-formyl-3-methoxy-phenoxy)-butyric acid