(E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

Base Information

Chemical Name:(E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol
CAS No.:182411-35-4
Molecular Formula:C₃₂H₄₈O₇Si
Molecular Weight:572.814
Hs Code.:

Synonyms:(E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

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Chemical Property of (E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

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Technology Process of (E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

There total 6 articles about (E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 182411-35-4
(E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / NaH / tetrahydrofuran / 15 h / Ambient temperature

2: 1.) (PPh₃)3RhCl, (i-Pr)2NEt, 2.) HgO, HgCl₂ / 1.) EtOH, reflux, 3 h, 2.) acetone, water, RT, 30 min

3: 67 percent / benzene / 6 h / Heating

4: 69 percent / TfOH / diethyl ether / Ambient temperature

5: 1.) DIBAL, 2.) NaBH₄, CeCl₃ / 1.) dichloromethane, hexane, -78 deg C, 30 min, 2.) MeOH, RT

With sodium tetrahydroborate; Wilkinson's catalyst; cerium(III) chloride; trifluorormethanesulfonic acid; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1016/0040-4020(96)00700-4

Reference yield:

: 182411-29-6
(3aS,4R,6S,7R,7aR)-6-Allyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol

: 182411-35-4
(E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / NaH / tetrahydrofuran / 15 h / Ambient temperature

2: 1.) (PPh₃)3RhCl, (i-Pr)2NEt, 2.) HgO, HgCl₂ / 1.) EtOH, reflux, 3 h, 2.) acetone, water, RT, 30 min

3: 67 percent / benzene / 6 h / Heating

4: 69 percent / TfOH / diethyl ether / Ambient temperature

5: 1.) DIBAL, 2.) NaBH₄, CeCl₃ / 1.) dichloromethane, hexane, -78 deg C, 30 min, 2.) MeOH, RT

With sodium tetrahydroborate; Wilkinson's catalyst; cerium(III) chloride; trifluorormethanesulfonic acid; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1016/0040-4020(96)00700-4

Reference yield:

: (3aS,4R,7R,7aS)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ol

: 182411-35-4
(E)-(S)-4-Benzyloxy-4-{(4R,5S)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / benzene / 6 h / Heating

2: 69 percent / TfOH / diethyl ether / Ambient temperature

3: 1.) DIBAL, 2.) NaBH₄, CeCl₃ / 1.) dichloromethane, hexane, -78 deg C, 30 min, 2.) MeOH, RT

With sodium tetrahydroborate; cerium(III) chloride; trifluorormethanesulfonic acid; diisobutylaluminium hydride; In diethyl ether; benzene;
DOI:10.1016/0040-4020(96)00700-4