3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Base Information

Chemical Name:3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine
CAS No.:887620-21-5
Molecular Formula:C₆₇H₇₁N₄O₁₀PSi
Molecular Weight:1151.38
Hs Code.:

3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Synonyms:3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Suppliers and Price of 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

There total 5 articles about 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887620-19-1
formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester

: 109420-85-1
5'-O-(4,4'-dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine

: 887620-21-5
3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Guidance literature:: With 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ja060112b

Reference yield:

: 887620-15-7
2-(methyldiphenylsilyl)ethyl chloroformate

: 887620-21-5
3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na / tetrahydrofuran / 2 h / Heating

1.2: tetrahydrofuran / 1 h / 20 °C

2.1: 3.9 g / 4,5-dicyanoimidazole / CH₂Cl₂ / 16 h / 20 °C

With 4,5-dicyano-1H-imidazole; sodium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja060112b

Reference yield:

: 56183-63-2
bis(diisopropylamino)chlorophosphine

: 887620-21-5
3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.17 h / 0 °C

2.1: Na / tetrahydrofuran / 2 h / Heating

2.2: tetrahydrofuran / 1 h / 20 °C

3.1: 3.9 g / 4,5-dicyanoimidazole / CH₂Cl₂ / 16 h / 20 °C

With lithium aluminium tetrahydride; 4,5-dicyano-1H-imidazole; sodium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja060112b