N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Base Information

Chemical Name:N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide
CAS No.:1380645-77-1
Molecular Formula:C₂₁H₂₀BrN₃O₃S
Molecular Weight:474.378
Hs Code.:

Synonyms:N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

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Technology Process of N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

There total 5 articles about N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 59489-71-3
5-amino-2-bromopyrazine

: 1380646-34-3
2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionic acid

: 1380645-77-1
N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Guidance literature:: 2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

5-amino-2-bromopyrazine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 300355-18-4
(4-methanesulfonyl-phenyl)-acetic acid methyl ester

: 1380645-77-1
N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: potassium hydroxide; water / ethanol / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 4 h / 20 °C

With oxalyl dichloride; water; sodium hydride; potassium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 90536-66-6
4-(methylsulfonyl)phenylacetic acid

: 1380645-77-1
N-(5-Bromo-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: potassium hydroxide; water / ethanol / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 4 h / 20 °C

With oxalyl dichloride; sulfuric acid; water; sodium hydride; potassium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;