2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid

Base Information

• Chemical Name: 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid
• CAS No.: 160885-93-8
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.391
• Mol file: 160885-93-8.mol

Synonyms:2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid

Chemical Property of 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid

Chemical Property:

• Melting Point: 105-107 °C
• Boiling Point: 551.8±33.0 °C(Predicted)
• Density: 1.232±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

N-Fmoc-DL-isovaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid

There total 2 articles about 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 2-amino-2-methylbutyric acid hydrochloride (72408-58-3) → 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid (160885-93-8)

Guidance literature:

2-amino-2-methylbutyric acid hydrochloride; With water; sodium carbonate;

(fluorenylmethoxy)carbonyl chloride; In 1,4-dioxane;

With hydrogenchloride; water;

DOI:10.1021/jo802058x

Reference yield: 79.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + DL-isovaline (595-39-1,465-58-7) → 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid (160885-93-8)

Guidance literature:

With sodium carbonate; In water; acetone;

DOI:10.1021/jo00107a020

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

DL-isovaline

2-amino-2-methylbutyric acid hydrochloride

Refernces

• 1、 Hjorringgaard, Claudia U.,Pedersen, Jan M.,Vosegaard, Thomas,Nielsen, Niels Chr,Skrydstrup, Troels. "An automatic solid-phase synthesis of peptaibols". supporting information; experimental part. p. 1329 - 1332. Retrieved 2009/08/08.