5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester

Base Information

• Chemical Name: 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester
• CAS No.: 773136-20-2
• Molecular Formula: C₉H₈BrNO₅
• Molecular Weight: 290.07
• Mol file: 773136-20-2.mol

Synonyms:5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester

Chemical Property of 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Ethyl5-bromo-2-hydroxy-3-nitrobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester

There total 2 articles about 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethanol (64-17-5) + 5-bromo-2-hydroxy-3-nitrobenzoic acid (10169-50-3) → 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester (773136-20-2)

Guidance literature:

With sulfuric acid; In toluene; for 72h; Inert atmosphere; Dean-Stark; Reflux;

DOI:10.1021/jm400138z

Reference yield:

5-bromosalicyclic acid (89-55-4) → 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester (773136-20-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 3 h / 0 °C / Inert atmosphere

2: sulfuric acid / toluene / 72 h / Inert atmosphere; Dean-Stark; Reflux

With sulfuric acid; nitric acid; In toluene;

DOI:10.1021/jm400138z

Reference yield: 99.0%

5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester (773136-20-2) + N,N-Dimethylthiocarbamoyl chloride (16420-13-6) → 5-bromo-2-dimethylthiocarbamoyloxy-3-nitrobenzoic acid ethyl ester (1090903-99-3)

Guidance literature:

5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

N,N-Dimethylthiocarbamoyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm400138z

upstream raw materials:

5-bromosalicyclic acid

ethanol

5-bromo-2-hydroxy-3-nitrobenzoic acid

Downstream raw materials:

5-bromo-2-dimethylcarbamoylsulfanyl-3-nitrobenzoic acid ethyl ester

C₁₀H₁₁BrN₂O₄S

2-[3-(5-bromo-2-dimethylcarbamoylsulfanyl-3-nitrobenzyl)-2-oxo-2,3-dihydrobenzoimidazol-1-ylmethyl]pentanoic acid ethyl ester

5-bromo-2-dimethylthiocarbamoyloxy-3-nitrobenzoic acid ethyl ester