Z-MET-OSU

Base Information

• Chemical Name: Z-MET-OSU
• CAS No.: 3392-01-6
• Molecular Formula: C17H20 N2 O6 S
• Molecular Weight: 380.42
• Mol file: 3392-01-6.mol

Synonyms:Succinimide,N-[(N-carboxy-L-methionyl)oxy]-, benzyl ester (7CI,8CI)

Chemical Property of Z-MET-OSU

Chemical Property:

• Refractive Index: 1.594
• PSA: 127.31000
• Density: 1.35g/cm³
• LogP: 1.97050

Purity/Quality:

≥ 96% (HPLC) ^*data from raw suppliers

Z-L-methionine N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-MET-OSU

There total 2 articles about Z-MET-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Cbz-Met-OH (1152-62-1) + 1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate (107960-02-1) → N-carbobenzoxy-L-methionine N-succinimidoyl ester (3392-01-6)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; acetonitrile; Ambient temperature;

DOI:10.1021/jo00388a005

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Cbz-Met-OH (1152-62-1) → N-carbobenzoxy-L-methionine N-succinimidoyl ester (3392-01-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 5 ℃;

DOI:10.1021/jm00395a022

Reference yield: 75.0%

methyl 8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonate (106174-54-3) + N-carbobenzoxy-L-methionine N-succinimidoyl ester (3392-01-6) → methyl N--8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonate (110512-40-8)

Guidance literature:

In tetrahydrofuran; methanol; for 1h; Ambient temperature;

DOI:10.1021/jm00395a022

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Cbz-Met-OH

1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate

Downstream raw materials:

N-(benzyloxycarbonyl)-L-methionyl-L-valine methyl ester

methyl N--8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonate

Z-Met-N-hydroxy-succinimidester