7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

Base Information

Chemical Name:7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal
CAS No.:1312467-63-2
Molecular Formula:C₃₈H₅₈O₇Si
Molecular Weight:654.96
Hs Code.:

Synonyms:7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

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Chemical Property of 7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

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Technology Process of 7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

There total 6 articles about 7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312467-62-1
3,20-bis(ethylenedioxy)-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-7β-ol

: 98-88-4
benzoyl chloride

: 1312467-54-1
7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal

: 1312467-63-2
7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

Guidance literature:: With pyridine; at 20 ℃; for 12h;

Reference yield:

: 80-75-1,22847-91-2
11-alpha-hydroxyprogesterone

: 1312467-63-2
7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux

2.1: 1H-imidazole / N,N-dimethyl-formamide / 264 h / 20 °C / Inert atmosphere

3.1: dipyridine chromium trioxide / dichloromethane / 5.15 h / 4 - 20 °C

4.1: hydrogen; pyridine / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 24 h / 30 °C / 760.05 Torr

5.1: L-Selectride / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

5.2: 0.5 h

6.1: pyridine / 12 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; dipyridine chromium trioxide; L-Selectride; toluene-4-sulfonic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 3386-06-9
11α-hydroxy-5-pregnene-3,20-dione-di-(ethylene ketal)

: 1312467-63-2
7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 264 h / 20 °C / Inert atmosphere

2.1: dipyridine chromium trioxide / dichloromethane / 5.15 h / 4 - 20 °C

3.1: hydrogen; pyridine / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 24 h / 30 °C / 760.05 Torr

4.1: L-Selectride / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

4.2: 0.5 h

5.1: pyridine / 12 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; dipyridine chromium trioxide; L-Selectride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;