7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal

Base Information

• Chemical Name: 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal
• CAS No.: 1312467-54-1
• Molecular Formula: C₃₈H₅₈O₇Si
• Molecular Weight: 654.96

Synonyms:7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal

Chemical Property of 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal

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Technology Process of 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal

There total 9 articles about 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3,20-bis-ethylenedioxy-11α-O-(tert-butyldimethylsilanyloxy)-5α-pregnan-7α-ol + benzoyl chloride (98-88-4) → 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal (1312467-54-1) + α-benzoyloxy-11α-O-(tert-butyl-dimethylsilanyloxy)-5α-pregnane-3,20-bis-ethyleneketal

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm501676v

Reference yield: 40.0%

3,20-bis-ethylenedioxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-7α-ol (1312467-53-0) + benzoyl chloride (98-88-4) → 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal (1312467-54-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jm501676v

Reference yield:

3,20-bis(ethylenedioxy)-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-7β-ol (1312467-62-1) + benzoyl chloride (98-88-4) → 7α-benzoyloxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis-ethyleneketal (1312467-54-1) + 7β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bisethyleneketal (1312467-63-2)

Guidance literature:

With pyridine; at 20 ℃; for 12h;

upstream raw materials:

3,20-bis-ethylenedioxy-11α-O-(tert-butyldimethylsilanyloxy)-5β-pregnan-7α-ol

benzoyl chloride

3,20-bis(ethylenedioxy)-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-7β-ol

11-alpha-hydroxyprogesterone

Downstream raw materials:

3,20-bis-ethylenedioxy-7α-benzoyloxy-5β-pregnan-11α-ol

7α-benzoyloxy-11α-hydroxy-5β-pregnane-3,20-dione

7α,11α-dibenzoyloxy-5β-pregnan-3,20-bisethyleneketal

7α,11α-dibenzoyloxy-5β-pregnane-3,20-dione

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