(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

Base Information

Chemical Name:(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide
CAS No.:1373443-19-6
Molecular Formula:C₃₁H₃₂N₂O₄
Molecular Weight:496.606
Hs Code.:

Synonyms:(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

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Chemical Property of (E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

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Technology Process of (E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

There total 4 articles about (E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.3%

: 617-89-0
furan-2-ylmethanamine

: 1373443-11-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid

: 1373443-19-6
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

Guidance literature:: With potassium carbonate; ammonium chloride; In N,N-dimethyl-formamide; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm301419d

Reference yield:

: 1373443-03-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

: 1373443-19-6
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

2: potassium carbonate; ammonium chloride / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

With lithium hydroxide monohydrate; potassium carbonate; ammonium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301419d

Reference yield:

: 29799-07-3
4-adamantylphenol

: 1373443-19-6
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-N-furan-2-ylmethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / toluene / 3 h / -10 - 115 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

5: potassium carbonate; ammonium chloride / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

With lithium hydroxide monohydrate; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm301419d