4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Base Information

Chemical Name:4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)
CAS No.:111199-75-8
Molecular Formula:C₁₈H₂₂N₄O₆
Molecular Weight:390.396
Hs Code.:

Synonyms:4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

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Chemical Property of 4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

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Technology Process of 4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

There total 4 articles about 4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 593-51-1
methylamine hydrochloride

: 111199-77-0
2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, diethyl ester

: 111199-75-8
4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Guidance literature:: With sodium acetate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jo00286a020

Reference yield:

: 111199-77-0
2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, diethyl ester

: 111199-75-8
4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Guidance literature:: With methylamine hydrochloride; sodium acetate; In N-methyl-acetamide;

Reference yield:

: 39562-16-8
ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

: 111199-75-8
4-methyl-2-(methylamino)-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / sodium bicarbonate / dimethylformamide / 24 h / 70 °C

2: pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 49 percent / sodium acetate / dimethylformamide / 24 h / Ambient temperature

With pyridine; sodium acetate; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00286a020